Analysis of APTT Based Clot Waveform Parameters in Various Clinical Conditions – A Study at A Tertiary Care Center

Various coagulation tests like Prothrombin Time (PT) and Activated Partial Thromboplastin (APTT) are estimated by automated analyzers. The newer fully analyzers generate clot wave forms aPTT-CWA for these parameters derived. In this study, the objective was to analyze form characteristics morphology its first second derivative values in cases with abnormal APTT. ACL TOP 300 generated curves APTT a total 125 patients 20 normal controls included. First derivative, of curve: sigmoid, biphasic, prolonged pre-coagulation phase, early late shoulder, biphasic peak, delayed deceleration were analyzed parameters. Wave included study. Patients (M:F - 2.2:1, mean age: 46.9 ± years). A spectrum clinical conditions Covid (20%), liver disease (23%), polytrauma (10.4%), cardiac diseases (8.8%), sepsis/DIC (7.2%), thromboembolism renal (6.4%), bacterial infections (4%), dengue snake bite (1.6%) factor deficiency (1.6%). Liver heart showed significant difference acceleration peaks followed sepsis, dengue, sepsis/DIC. Deceleration peak (p<0.05). Sepsis CWA is very easily available on all It inexpensive fast turn round time. Both quantitative as well qualitative informations such velocity, formation pattern details recorded. Our study highlights importance acquired performing test